MOMAST® Reduces the Plasmatic Lipid Profile and Oxidative Stress and Regulates Cholesterol Metabolism in a Hypercholesterolemic Mouse Model: The Proof of Concept of a Sustainable and Innovative Antioxidant and Hypocholesterolemic Ingredient

MOMAST® is a patented natural phenolic complex, rich in tyrosol (9.0 g/kg, Tyr), hydroxityrosol (43,5 OH-Tyr), and verbascoside (5.0 g/Kg), which obtained from the OVW by-product of Coratina cultivar with potent direct antioxidant activity (measured by DPPH FRAP assays, respectively). Indeed, represents an innovative sustainable bioactive ingredient has been ethical empowering behavior applying principles circular economy. In framework research aimed at fostering its health-promoting activity, this study it was clearly demonstrated that treatment reduced oxidative stress levels total cholesterol (TC) low-density lipoprotein (LDL) cholesterol, increased HDL levels, without changes triglyceride (TG) Western diet (WD)-fed mice. The modulation plasmatic lipid profile similar to red yeast rice (RYR) containing Monacolin K (3%). addition, molecular level liver homogenates, similarly RYR, exerts cholesterol-lowering through activation LDL receptor, whereas, unlike reduces proprotein convertase subtilisin/kexin type 9 (PCSK9) protein via hepatic nuclear factor 1 (HNF1)-α activation. Hence, provides proof concept regarding hypocholesterolemic MOMAST, could be successfully exploited as active for development dietary supplements functional foods.